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Spectroscopic and light scattering methods were used to gain insight into the existence
and characterization of the cancer stem cell. Fundamental technical description of devices
used have been reported elsewhere. We included alterations and implementation of these
biophotonic instruments as applied to our objectives. We disassociated human tumor and
submitted the cells to optical characterization to support our working hypothesis of stem
cell origins to cancer and mechanisms. Single cell combined with population based
analysis within the Pancreatic cancer system led us to information regarding the
polarization state of cells possessing anchor proteins and drug influx pumps.
Multispectral imaging combined with flow cytometry enabled us to target rare cells that
appear to retain template DNA. rendering them resistant to anti-cancer drug therapy. In
this study we describe an optical method that combines high-throughput population
pattern and correlates each cell with an individual fluorescent and bright-field image.
G. Wiegand,H. Xin,A. Anderson,J. Mullinax,K. Jaiswal,A. Wiegand, andItzhak Avital
"Cellular spectroscopy: applications to cancer stem cell characterization", Proc. SPIE 7902, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 79021G (11 February 2011); https://doi.org/10.1117/12.875458
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G. Wiegand, H. Xin, A. Anderson, J. Mullinax, K. Jaiswal, A. Wiegand, Itzhak Avital, "Cellular spectroscopy: applications to cancer stem cell characterization," Proc. SPIE 7902, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 79021G (11 February 2011); https://doi.org/10.1117/12.875458