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Proceedings Article

The study of the correlation properties on RBC flickering using double-path interferometric quantitative phase microscopy

[+] Author Affiliations
Seungrag Lee, Ji Yong Lee, Chang-Soo Park

Gwangju Institute of Science and Technology (Korea, Republic of)

Dug Young Kim

Yonsei Univ. (Korea, Republic of)

Proc. SPIE 7902, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 79021U (February 10, 2011); doi:10.1117/12.874100
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From Conference Volume 7902

  • Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX
  • Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif
  • San Francisco, California, USA | January 22, 2011

abstract

We present the study of the correlation properties of RBC flickering using double-path interferometric quantitative phase microscopy (QPM) using detrended fluctuation analysis (DFA). For DFA of RBC membrane fluctuations, we have measured time series thickness variations of a normal RBC for 20 seconds. The amplitude of membrane fluctuations in RBC have showed significantly larger than the background noise level without a RBC. We have demonstrated a practical DFA application for QPM by studying the correlation property of RBC membrane fluctuations in a noninvasive manner. By measuring the fractal scaling exponents of the time series RBC thickness variations obtained from QPM, we have analyzed the correlation properties of RBC membrane fluctuations and the background noise without a sample. The exponents for a normal RBC revealed the long-range correlation property in time series during 20 seconds. However, the averaged exponent for background noise outside a cell was close to the exponent of white noise.

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Citation

Seungrag Lee ; Ji Yong Lee ; Chang-Soo Park and Dug Young Kim
"The study of the correlation properties on RBC flickering using double-path interferometric quantitative phase microscopy", Proc. SPIE 7902, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 79021U (February 10, 2011); doi:10.1117/12.874100; http://dx.doi.org/10.1117/12.874100


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