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Proceedings Article

Dependence of third-harmonic generation on melanin concentration in solution

[+] Author Affiliations
Tung-Yu Su, Chien-Sheng Liao, Chih-Yuan Yang, Zong-Yan Zhuo, Szu-Yu Chen, Shi-Wei Chu

National Taiwan Univ. (Taiwan)

Proc. SPIE 7903, Multiphoton Microscopy in the Biomedical Sciences XI, 79030I (February 10, 2011); doi:10.1117/12.872837
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From Conference Volume 7903

  • Multiphoton Microscopy in the Biomedical Sciences XI
  • Ammasi Periasamy; Karsten König; Peter T. C. So
  • San Francisco, California, USA | January 22, 2011

abstract

In this study, we performed theoretical analysis and experimental measurement of third harmonic generation (THG) in melanin solution with different concentrations. As predicted by theory, only THG at glass/solution interface was observed due to Guoy phase shift effect. We have shown that this interfacial THG intensity is strongly affected by index matching condition between the two media, leading to minimal THG at a certain melanin concentration. By fitting the dependence of THG intensity versus melanin concentration, linear and nonlinear electric susceptibilities of melanin are obtained, providing a valuable tool to characterize optical properties of biological molecules.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Tung-Yu Su ; Chien-Sheng Liao ; Chih-Yuan Yang ; Zong-Yan Zhuo ; Szu-Yu Chen, et al.
"Dependence of third-harmonic generation on melanin concentration in solution", Proc. SPIE 7903, Multiphoton Microscopy in the Biomedical Sciences XI, 79030I (February 10, 2011); doi:10.1117/12.872837; http://dx.doi.org/10.1117/12.872837


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