Dependence of third-harmonic generation on melanin concentration in solution

Tung-Yu Su; Chien-Sheng Liao; Chih-Yuan Yang; Zong-Yan Zhuo; Szu-Yu Chen; Shi-Wei Chu

doi:10.1117/12.872837

11 February 2011 Dependence of third-harmonic generation on melanin concentration in solution

Tung-Yu Su, Chien-Sheng Liao, Chih-Yuan Yang, Zong-Yan Zhuo, Szu-Yu Chen, Shi-Wei Chu

Proceedings Volume 7903, Multiphoton Microscopy in the Biomedical Sciences XI; 79030I (2011) https://doi.org/10.1117/12.872837
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this study, we performed theoretical analysis and experimental measurement of third harmonic generation (THG) in melanin solution with different concentrations. As predicted by theory, only THG at glass/solution interface was observed due to Guoy phase shift effect. We have shown that this interfacial THG intensity is strongly affected by index matching condition between the two media, leading to minimal THG at a certain melanin concentration. By fitting the dependence of THG intensity versus melanin concentration, linear and nonlinear electric susceptibilities of melanin are obtained, providing a valuable tool to characterize optical properties of biological molecules.

Citation Download Citation

Tung-Yu Su, Chien-Sheng Liao, Chih-Yuan Yang, Zong-Yan Zhuo, Szu-Yu Chen, and Shi-Wei Chu "Dependence of third-harmonic generation on melanin concentration in solution", Proc. SPIE 7903, Multiphoton Microscopy in the Biomedical Sciences XI, 79030I (11 February 2011); https://doi.org/10.1117/12.872837

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KEYWORDS

Interfaces

Glasses

Refractive index

Phase shifts

Skin

Microscopy

Harmonic generation

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