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Proceedings Article

Nanosurgery with near-infrared 12-femtosecond and picosecond laser pulses

[+] Author Affiliations
Aisada Uchugonova

Univ. des Saarlandes (Germany) and Univ. of California, San Diego (USA)

Huijing Zhang

Univ. des Saarlandes (Germany)

Cornelius Lemke

Univ. of Jena (Germany)

Karsten König

Univ. des Saarlandes (Germany) and Beckman Laser Institute (USA)

Proc. SPIE 7903, Multiphoton Microscopy in the Biomedical Sciences XI, 79031N (February 10, 2011); doi:10.1117/12.875032
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From Conference Volume 7903

  • Multiphoton Microscopy in the Biomedical Sciences XI
  • Ammasi Periasamy; Karsten König; Peter T. C. So
  • San Francisco, California, USA | January 22, 2011

abstract

Laser-assisted surgery based on multiphoton absorption of NIR laser light has great potential for high precision surgery at various depths within the cells and tissues. Clinical applications include refractive surgery (fs-LASIK). The non-contact laser method also supports contamination-free cell nanosurgery. Here we apply femtosecond laser scanning microscopes for sub-100 nm surgery of human cells and metaphase chromosomes. A mode-locked 85 MHz Ti:Sapphire laser with an M-shaped ultrabroad band spectrum (maxima: 770 nm/830 nm) with an in situ pulse duration at the target ranging from 12 femtoseconds up to 3 picoseconds was employed. The effects of laser nanoprocessing in cells and chromosomes have been quantified by atomic force microscopy (AFM) and electron microscopy. These studies demonstrate the potential of extreme ultrashort femtosecond laser pulses at low mean milliwatt powers for sub-100 nm surgery.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Aisada Uchugonova ; Huijing Zhang ; Cornelius Lemke and Karsten König
"Nanosurgery with near-infrared 12-femtosecond and picosecond laser pulses", Proc. SPIE 7903, Multiphoton Microscopy in the Biomedical Sciences XI, 79031N (February 10, 2011); doi:10.1117/12.875032; http://dx.doi.org/10.1117/12.875032


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