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Proceedings Article

A multispectral FLIM tomograph for in-vivo imaging of skin cancer

[+] Author Affiliations
C. B. Talbot, R. Patalay, I. Munro, Y. Alexandrov, S. Warren, M. A. A. Neil, Paul M. W. French, Christopher Dunsby

Imperial College London (United Kingdom)

H. G. Breunig, K. König

JenLab GmbH (Germany)

A. Chu

Imperial College Healthcare NHS Trust (United Kingdom)

G. W. Stamp

The Royal Marsden Hospital NHS Trust (United Kingdom)

Proc. SPIE 7903, Multiphoton Microscopy in the Biomedical Sciences XI, 79032B (February 28, 2011); doi:10.1117/12.873567
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From Conference Volume 7903

  • Multiphoton Microscopy in the Biomedical Sciences XI
  • Ammasi Periasamy; Karsten König; Peter T. C. So
  • San Francisco, California, USA | January 22, 2011

abstract

To aid the in vivo diagnosis of skin lesions, we present the design and implementation of a 4 channel FLIM detector and a hyperspectral imaging detector into a clinically licensed commercial two-photon tomograph. We have also implemented image segmentation algorithms to facilitate the automated processing of the large volumes of data produced. The first detector is based on multispectral time correlated single photon counting, providing four channel fluorescence lifetime images. The second detector is a prism-based CCD hyperspectral imager. These detectors provide the capability to extract the relative content and state of autofluorescence compounds present in biological tissue.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

C. B. Talbot ; R. Patalay ; I. Munro ; H. G. Breunig ; K. König, et al.
"A multispectral FLIM tomograph for in-vivo imaging of skin cancer", Proc. SPIE 7903, Multiphoton Microscopy in the Biomedical Sciences XI, 79032B (February 28, 2011); doi:10.1117/12.873567; http://dx.doi.org/10.1117/12.873567


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