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Proceedings Article

Fourier analysis of mitochondrial distribution in oocytes

[+] Author Affiliations
Joseph L. Hollmann, Dana H. Brooks, Carol M. Warner, Charles A. DiMarzio

Northeastern Univ. (USA)

Judith A. Newmark

Northeastern Univ. (USA) and CompuCyte (USA)

Proc. SPIE 7904, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XVIII, 790419 (February 22, 2011); doi:10.1117/12.876345
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From Conference Volume 7904

  • Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XVIII
  • Jose-Angel Conchello; Carol J. Cogswell; Tony Wilson; Thomas G. Brown
  • San Francisco, California, USA | January 22, 2011

abstract

This paper describes a novel approach to quantifying mitochondrial patterns which are typically described using the qualitative terms "diffuse" "aggregated" and are potentially key indicators for an oocyte's health and survival potential post-implantation. An oocyte was isolated in a confocal image and a coarse grid was superimposed upon it. The spatial spectrum was calculated and an aggregation factor was generated. A classifier for healthy cells was developed and verified. The aggregation factor showed a clear distinction between the healthy and unhealthy oocytes. The ultimate goal is to screen oocytes for viability preimplantation, thus improving the outcome of in vitro fertilization (IVF) treatments.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Joseph L. Hollmann ; Dana H. Brooks ; Judith A. Newmark ; Carol M. Warner and Charles A. DiMarzio
"Fourier analysis of mitochondrial distribution in oocytes", Proc. SPIE 7904, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XVIII, 790419 (February 22, 2011); doi:10.1117/12.876345; http://dx.doi.org/10.1117/12.876345


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