Noninvasive in vivo Glucose Sensing using an iris based technique

Anthony J. Webb; Brent D. Cameron

doi:10.1117/12.875160

10 February 2011 Noninvasive in vivo glucose sensing using an iris based technique

Anthony J. Webb, Brent D. Cameron

Proceedings Volume 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III; 79060C (2011) https://doi.org/10.1117/12.875160
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Physiological glucose monitoring is important aspect in the treatment of individuals afflicted with diabetes mellitus. Although invasive techniques for glucose monitoring are widely available, it would be very beneficial to make such measurements in a noninvasive manner. In this study, a New Zealand White (NZW) rabbit animal model was utilized to evaluate a developed iris-based imaging technique for the in vivo measurement of physiological glucose concentration. The animals were anesthetized with isoflurane and an insulin/dextrose protocol was used to control blood glucose concentration. To further help restrict eye movement, a developed ocular fixation device was used. During the experimental time frame, near infrared illuminated iris images were acquired along with corresponding discrete blood glucose measurements taken with a handheld glucometer. Calibration was performed using an image based Partial Least Squares (PLS) technique. Independent validation was also performed to assess model performance along with Clarke Error Grid Analysis (CEGA). Initial validation results were promising and show that a high percentage of the predicted glucose concentrations are within 20% of the reference values.

Citation Download Citation

Anthony J. Webb and Brent D. Cameron "Noninvasive in vivo glucose sensing using an iris based technique", Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060C (10 February 2011); https://doi.org/10.1117/12.875160

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KEYWORDS

Glucose

Iris

Blood

In vivo imaging

Eye

Error analysis

Eye models

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