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Clinical guidelines dictate that frequent blood glucose monitoring in diabetic patients is critical towards proper
management of the disease. Although, several different types of glucose monitors are now commercially available,
most of these devices are invasive, thereby adversely affecting patient compliance. To this end, optical polarimetric
glucose sensing through the eye has been proposed as a potential noninvasive means to aid in the control of diabetes.
Arguably, the most critical and limiting factor towards successful application of such a technique is the time varying
corneal birefringence due to eye motion artifact. We present a spatially variant uniaxial eye model to serve as a tool
towards better understanding of the cornea's birefringence properties. The simulations show that index-unmatched
coupling of light is spatially limited to a smaller range when compared to the index-matched situation. Polarimetric
measurements on rabbits' eyes indicate relative agreement between the modeled and experimental values of corneal
birefringence. In addition, the observed rotation in the plane of polarized light for multiple wavelengths
demonstrates the potential for using a dual-wavelength polarimetric approach to overcome the noise due to timevarying
corneal birefringence. These results will ultimately aid us in the development of an appropriate eye coupling
mechanism for in vivo polarimetric glucose measurements.
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