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Proceedings Article

The high-quality spectral fingerprint of glucose captured by Raman spectroscopy in non-invasive glucose measurement

[+] Author Affiliations
Jeankun Oh, Seongmoon Cho, Hyunho Oh, Yunhee Ku, BongChu Shim, Moosub Kim, Yongju Yang, Dami Kim, Hyejin Eum, David R. Miller

LG Electronics Inc. (Korea, Republic of)

Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060G (February 10, 2011); doi:10.1117/12.874314
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From Conference Volume 7906

  • Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III
  • Robert J. Nordstrom; Gerard L. Coté
  • San Francisco, California, USA | January 22, 2011

abstract

Optical spectroscopy has the inherent advantage of directly measuring glucose levels by means of the unique nature of a spectral fingerprint for the target analyte, glucose, which is determined in the form of a calibration spectrum (a product of multivariate analysis method). The literature is replete with claims of successful in-vivo glucose measurements in terms of Clark error grid analysis. However, all of them fail to demonstrate an in vivo glucose-specific calibration spectrum. In this study we use Raman spectroscopy to capture a high quality spectral fingerprint of the glucose molecule noninvasively and demonstrate calculated correlation coefficients between a pure glucose spectrum and calibration spectra at over 0.8.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Jeankun Oh ; Seongmoon Cho ; Hyunho Oh ; Yunhee Ku ; BongChu Shim, et al.
"The high-quality spectral fingerprint of glucose captured by Raman spectroscopy in non-invasive glucose measurement", Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060G (February 10, 2011); doi:10.1117/12.874314; http://dx.doi.org/10.1117/12.874314


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