Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

An effective method based on reference point for glucose sensing at 1100-1600nm

[+] Author Affiliations
Jiaxiang Zheng, Kexin Xu, Yue Yang

Tianjin Univ. (China)

Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060X (February 10, 2011); doi:10.1117/12.873045
Text Size: A A A
From Conference Volume 7906

  • Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III
  • Robert J. Nordstrom; Gerard L. Coté
  • San Francisco, California, USA | January 22, 2011

abstract

Non-invasive blood glucose sensing by near-infrared spectroscopy is easily interrupted by the strong background variations compared to the weak glucose signals. In this work, according to the distribution of diffuse reflectance intensity at different source-detector separations, a method based on a reference point and a measuring point, where the diffuse reflectance intensity is insensitive and most sensitive to the variation of glucose concentration, respectively, is applied. And the data processing method based on the information of two points is investigated to improve the precision of glucose sensing. Based on the Monte Carlo simulation in 5% intralipid solution model, the corresponding optical probe is designed which includes two detecting points: a reference point located at 1.3-1.7mm and a measuring point located at 1.7-2.1mm. Using the probe, the in vitro experiment with different glucose concentrations in the intralipid solution is conducted at 1100-1600nm. As a result, compared to the PLS model built by the signal of the measuring point, the root mean square error of prediction (RMSEP) and root mean square error of cross calibration (RMSEC) of the corrected model built by reference point and measuring point reduces by 45.10%, and 32.15% respectively.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Jiaxiang Zheng ; Kexin Xu and Yue Yang
"An effective method based on reference point for glucose sensing at 1100-1600nm", Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060X (February 10, 2011); doi:10.1117/12.873045; http://dx.doi.org/10.1117/12.873045


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.