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Proceedings Article

Nanoscale nuclear architecture for cancer diagnosis by spatial-domain low-coherence quantitative phase microscopy

[+] Author Affiliations
Pin Wang, Rajan K. Bista, Kevin D. Staton, Randall E. Brand, Yang Liu

Univ. of Pittsburgh (USA)

Walid E. Khalbuss, Wei Qiu

Univ. of Pittsburgh Medical Ctr. Shadyside (USA)

Lin Zhang

Univ. of Pittsburgh Cancer Institute (USA)

Teresa A. Brentnall

Univ. of Washington (USA)

Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790704 (February 11, 2011); doi:10.1117/12.874693
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From Conference Volume 7907

  • Biomedical Applications of Light Scattering V
  • Adam P. Wax; Vadim Backman
  • San Francisco, California, USA | January 22, 2011

abstract

Alterations in nuclear architecture are the hallmark diagnostic characteristic of cancer cells. In this work, we show that the nuclear architectural characteristics quantified by spatial-domain low-coherence quantitative phase microscopy (SL-QPM), is more sensitive for the identification of cancer cells than conventional cytopathology. We demonstrated the importance of nuclear architectural characteristics in both an animal model of intestinal carcinogenesis - APC/Min mouse model and human cytology specimens with colorectal cancer by identifying cancer from cytologically noncancerous appearing cells. The determination of nanoscale nuclear architecture using this simple and practical optical instrument is a significant advance towards cancer diagnosis.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Pin Wang ; Rajan K. Bista ; Walid E. Khalbuss ; Wei Qiu ; Kevin D. Staton, et al.
"Nanoscale nuclear architecture for cancer diagnosis by spatial-domain low-coherence quantitative phase microscopy", Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790704 (February 11, 2011); doi:10.1117/12.874693; http://dx.doi.org/10.1117/12.874693


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