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Proceedings Article

Fourier domain low coherence interferometry for detection of early colorectal cancer development in the AOM rat model

[+] Author Affiliations
Francisco E. Robles, Yizheng Zhu, Adam Wax

Duke Univ. (USA)

Jin Lee, Sheela Sharma

The Hamner Institutes for Health Sciences (USA)

Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790712 (February 11, 2011); doi:10.1117/12.872929
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From Conference Volume 7907

  • Biomedical Applications of Light Scattering V
  • Adam P. Wax; Vadim Backman
  • San Francisco, California, USA | January 22, 2011

abstract

We present Fourier domain low coherence interferometry (fLCI) applied to the detection of preneoplastic changes in the colon using the ex-vivo azoxymethane (AOM) rat carcinogenesis model. fLCI measures depth resolved spectral oscillations, also known as local oscillations, resulting from coherent fields induced by the scattering of cell nuclei. The depth resolution of fLCI permits nuclear morphology measurements within thick tissues, making the technique sensitive to the earliest stages of precancerous development. To achieve depth resolved spectroscopic analysis, we use the dual window method, which obtains simultaneously high spectral and depth resolution and yields access to the local oscillations. The results show highly statistically significant differences between the AOM-treated and control group samples. Further, the results suggest that fLCI may be used to detect the field effect of carcinogenesis, in addition to identifying specific areas where more advanced neoplastic development has occurred.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Francisco E. Robles ; Yizheng Zhu ; Jin Lee ; Sheela Sharma and Adam Wax
"Fourier domain low coherence interferometry for detection of early colorectal cancer development in the AOM rat model", Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790712 (February 11, 2011); doi:10.1117/12.872929; http://dx.doi.org/10.1117/12.872929


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