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Proceedings Article

Compact intraoperative imaging device for sentinel lymph node mapping

[+] Author Affiliations
Yang Liu, Adam Q. Bauer, Walter Akers, Gail Sudlow, Kexian Liang, Duanwen Shen, Mikhail Berezin, Joseph P. Culver, Samuel Achilefu

Washington Univ. in St. Louis (USA)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100D (February 11, 2011); doi:10.1117/12.886226
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From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

We have developed a novel real-time intraoperative fluorescence imaging device that can detect near-infrared (NIR) fluorescence and map sentinel lymph nodes (SLNs). In contrast to conventional imaging systems, this device is compact, portable, and battery-operated. It is also wearable and thus allows hands-free operation of clinicians. The system directly displays the fluorescence in its goggle eyepiece, eliminating the need for a remote monitor. Using this device in murine lymphatic mapping, the SLNs stained with indocyanine green (ICG) can be readily detected. Fluorescence-guided SLN resection under the new device was performed with ease. Ex vivo examination of resected tissues also revealed high fluorescence level in the SLNs. Histology further confirmed the lymphatic nature of the resected SLNs.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Yang Liu ; Adam Q. Bauer ; Walter Akers ; Gail Sudlow ; Kexian Liang, et al.
"Compact intraoperative imaging device for sentinel lymph node mapping", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100D (February 11, 2011); doi:10.1117/12.886226; http://dx.doi.org/10.1117/12.886226


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