In vivo monitoring of organ-selective distribution of CdHgTe/SiO2 nanoparticles in mouse model

Haiyan Chen; Sisi Cui; Hongyan Zhu; Zhenzhen Tu; Lingling Shan; Jianpeng Xue; Dawei Deng; Jun Zhang; Yueqing Gu

doi:10.1117/12.873350

11 February 2011 In vivo monitoring of organ-selective distribution of CdHgTe/SiO₂ nanoparticles in mouse model

Haiyan Chen, Sisi Cui, Hongyan Zhu, Zhenzhen Tu, Lingling Shan, Jianpeng Xue, Dawei Deng, Jun Zhang, Yueqing Gu

Proceedings Volume 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III; 79100S (2011) https://doi.org/10.1117/12.873350
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

CdHgTe/SiO₂ nanoparticles were prepared by SiO₂ capping on the surface of CdHgTe quantum dots (QDs). The characteristics, such as optical spectra, size and optical stability were investigated. The size of CdHgTe/SiO₂ nanoparticles could be larger than 100 nm after CdHgTe QDs capped with SiO₂. CdHgTe/SiO₂ nanoparticles acted as a novel fluorescence probe have a maximum fluorescence emission of 790 nm and a full width at half-maximum (FWHM) of 50-70 nm. The in vivo fluorescence imaging of CdHgTe/SiO₂ nanoparticles in mouse model indicated the nanoparticles could be passively targeting to lung and liver. CdHgTe/SiO₂ nanoparticles offer new perspectives for size dependent bio-dstribution studies in living body.

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Haiyan Chen, Sisi Cui, Hongyan Zhu, Zhenzhen Tu, Lingling Shan, Jianpeng Xue, Dawei Deng, Jun Zhang, and Yueqing Gu "In vivo monitoring of organ-selective distribution of CdHgTe/SiO₂ nanoparticles in mouse model", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79100S (11 February 2011); https://doi.org/10.1117/12.873350

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KEYWORDS

Nanoparticles

Luminescence

In vivo imaging

Silica

Lung

Liver

Mouse models

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