Full Content is available to subscribers

Subscribe/Learn More  >
Proceedings Article

Fabrication and optical stability of silanized gold nanorods as multifunctional transducers of near infrared light

[+] Author Affiliations
Fulvio Ratto, Paolo Matteini, Francesca Rossi, Roberto Pini

Istituto di Fisica Applicata Nello Carrara (Italy)

Sonia Centi, Franco Fusi

Univ. degli Studi di Firenze (Italy)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101E (February 11, 2011); doi:10.1117/12.875157
Text Size: A A A
From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

We give new insight into multifunctional nanoparticles with light extinction in the therapeutic window, optical stability even on aggregation, as well as possibility of bio-conjugation. The optical response of these particles rests on gold nanorods, which interact with near infrared (NIR) light via plasmonic oscillations, i.e. a boundary effect which depends on all physiochemical conditions at the interface with their environment. Therefore their feasibility for biomedical applications is challenged by a poor definition of their dispersion medium, aggregation (e.g. inside endocytic vesicles) and shape transformations, which typically occur in the biological sample and under excitation and jeopardize their optical features. Here silanization of the gold nanorods is proposed as one effective solution to overcome these issues. A shell of porous silica confers isolation from the local environment and additional stability, and also proves suitable for PEGylation and bio-conjugation with e.g. biological macromolecules. In particular we engineer models of aggregation of these particles, in order to investigate its principal effect on their optical response. While in the absence of silica gold nanorods undergo substantial degradation of their plasmon oscillations, silanization proves excellent to maintain pristine optical properties even after critical flocculation.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Fulvio Ratto ; Paolo Matteini ; Sonia Centi ; Francesca Rossi ; Franco Fusi, et al.
"Fabrication and optical stability of silanized gold nanorods as multifunctional transducers of near infrared light", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101E (February 11, 2011); doi:10.1117/12.875157; http://dx.doi.org/10.1117/12.875157


Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).

Figures

Tables

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Advertisement


 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Proceeding
Sign in or Create a personal account to Buy this proceeding ($15 for members, $18 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.