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Proceedings Article

Gold nanorods for applications in biological imaging

[+] Author Affiliations
Y. Zhang, J. Yu, D. J. S. Birch, Y. Chen

Univ. of Strathclyde (United Kingdom)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101H (February 11, 2011); doi:10.1117/12.877156
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From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

Two-Photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging for high resolution, low photo-damage, tunable near infra-red (NIR) longitudinal band, polarization dependence, ability to conjugate to bio-molecules and low toxicity. Here we demonstrate the application of gold nanorods as TPL imaging agents by studying the gold nanorods taken up by Madin-Darby canine kidney (MDCK) cells using both confocal imaging and fluorescence lifetime imaging microscopy (FLIM). The characteristic luminescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Y. Zhang ; J. Yu ; D. J. S. Birch and Y. Chen
"Gold nanorods for applications in biological imaging", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101H (February 11, 2011); doi:10.1117/12.877156; http://dx.doi.org/10.1117/12.877156


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