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Proceedings Article

Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage

[+] Author Affiliations
Niculae Mincu, Dao Chao Huang, Marilyse Piche, Guobin Ma

Advanced Research Technologies Inc. (Canada)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101K (February 11, 2011); doi:10.1117/12.875214
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From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

The continuously expanding number of fluorescent probes developed for molecular imaging in vivo requires new instruments, more flexible and with higher quantification power. Responding to those requirements we propose a new instrument: it combines the sensitivity of time correlated single photon detection with the extended spectral coverage of a pulsed supercontinuum laser in a sensitive and flexible time-domain platform for in vivo molecular imaging in small animals. The performance of the system is demonstrated on a case study, using NEO-STEM-PMSR50- PEG fluorescent silica nanoprobes and sequential imaging of CD-1 nude mice.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Niculae Mincu ; Dao Chao Huang ; Marilyse Piche and Guobin Ma
"Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101K (February 11, 2011); doi:10.1117/12.875214; http://dx.doi.org/10.1117/12.875214


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