CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 7910 > Article
Open Access Paper
16 February 2011 Imaging enabled platforms for development of therapeutics
Jonathan Celli, Imran Rizvi, Adam R Blanden, Conor L. Evans, Adnan O. Abu-Yousif, Bryan Q. Spring, Alona Muzikansky, Brian W. Pogue, Dianne M. Finkelstein, Tayyaba Hasan
Author Affiliations +
Proceedings Volume 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III; 791002 (2011) https://doi.org/10.1117/12.877293
Event: SPIE BiOS, 2011, San Francisco, California, United States
Abstract
Advances in imaging and spectroscopic technologies have enabled the optimization of many therapeutic modalities in cancer and noncancer pathologies either by earlier disease detection or by allowing therapy monitoring. Amongst the therapeutic options benefiting from developments in imaging technologies, photodynamic therapy (PDT) is exceptional. PDT is a photochemistry-based therapeutic approach where a light-sensitive molecule (photosensitizer) is activated with light of appropriate energy (wavelength) to produce reactive molecular species such as free radicals and singlet oxygen. These molecular entities then react with biological targets such as DNA, membranes and other cellular components to impair their function and lead to eventual cell and tissue death. Development of PDT-based imaging also provides a platform for rapid screening of new therapeutics in novel in vitro models prior to expensive and labor-intensive animal studies. In this study we demonstrate how an imaging platform can be used for strategizing a novel combination treatment strategy for multifocal ovarian cancer. Using an in vitro 3D model for micrometastatic ovarian cancer in conjunction with quantitative imaging we examine dose and scheduling strategies for PDT in combination with carboplatin, a chemotherapeutic agent presently in clinical use for management of this deadly form of cancer.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Jonathan Celli, Imran Rizvi, Adam R Blanden, Conor L. Evans, Adnan O. Abu-Yousif, Bryan Q. Spring, Alona Muzikansky, Brian W. Pogue, Dianne M. Finkelstein, and Tayyaba Hasan "Imaging enabled platforms for development of therapeutics", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791002 (16 February 2011); https://doi.org/10.1117/12.877293
PROCEEDINGS
 8 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 2 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Photodynamic therapy
3D modeling
3D image processing
Tumors
Cancer
Molecules
Ovarian cancer
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top