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Proceedings Article

Novel design of multimodal MRI/NIR optical contrast agent

[+] Author Affiliations
Kevin Guo, Franck Lin, Walter Akers, Jie Zheng, Mikhail Y. Berezin, Samuel Achilefu

Washington Univ. in St. Louis (USA)

Bao Teng, Olga Vasalatiy, Gary L. Griffiths, Amir Gandjbakhche

National Institutes of Health (USA)

Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791015 (February 11, 2011); doi:10.1117/12.881395
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From Conference Volume 7910

  • Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III
  • Samuel Achilefu; Ramesh Raghavachari
  • San Francisco, California, USA | January 22, 2011

abstract

We present a novel, dual modality gadolinium based MRI/near-infrared optical probe. Utilizing a fluorescent dye as a scaffold with attached Gd-chelating moiety, we demonstrated a substantial shortening of T1 relaxation time of water protons in vitro . The probe was compared to the commonly used MRI Gd-based contrast agents Magnevist® and Multihance® and showed superior contrast properties. The enhancement was due to strong albumin binding of the hydrophobic fluorophore and overall rigidification of the contrast agent. Due to the near-infrared optical properties of the probe and excellent MRI activity the proposed construct can be potentially utilized as a dual probe in multimodal MRI/NIR optical imaging.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Kevin Guo ; Franck Lin ; Walter Akers ; Jie Zheng ; Bao Teng, et al.
"Novel design of multimodal MRI/NIR optical contrast agent", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791015 (February 11, 2011); doi:10.1117/12.881395; http://dx.doi.org/10.1117/12.881395


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