Novel design of multimodal MRI/NIR optical contrast agent

Kevin Guo; Franck Lin; Walter Akers; Jie Zheng; Bao Teng; Olga Vasalatiy; Gary L. Griffiths; Amir Gandjbakhche; Mikhail Y. Berezin; Samuel Achilefu

doi:10.1117/12.881395

11 February 2011 Novel design of multimodal MRI/NIR optical contrast agent

Kevin Guo, Franck Lin, Walter Akers, Jie Zheng, Bao Teng, Olga Vasalatiy, Gary L. Griffiths, Amir Gandjbakhche, Mikhail Y. Berezin, Samuel Achilefu

Author Affiliations +

Proceedings Volume 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III; 791015 (2011) https://doi.org/10.1117/12.881395
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We present a novel, dual modality gadolinium based MRI/near-infrared optical probe. Utilizing a fluorescent dye as a scaffold with attached Gd-chelating moiety, we demonstrated a substantial shortening of T1 relaxation time of water protons in vitro. The probe was compared to the commonly used MRI Gd-based contrast agents Magnevist® and Multihance® and showed superior contrast properties. The enhancement was due to strong albumin binding of the hydrophobic fluorophore and overall rigidification of the contrast agent. Due to the near-infrared optical properties of the probe and excellent MRI activity the proposed construct can be potentially utilized as a dual probe in multimodal MRI/NIR optical imaging.

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Kevin Guo, Franck Lin, Walter Akers, Jie Zheng, Bao Teng, Olga Vasalatiy, Gary L. Griffiths, Amir Gandjbakhche, Mikhail Y. Berezin, and Samuel Achilefu "Novel design of multimodal MRI/NIR optical contrast agent", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 791015 (11 February 2011); https://doi.org/10.1117/12.881395

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