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Proceedings Article

Aptamer-based localized surface plasmon resonance sensor for monitoring glycated proteins

[+] Author Affiliations
Rui Zheng, Brent D. Cameron

The Univ. of Toledo (USA)

Proc. SPIE 7911, Plasmonics in Biology and Medicine VIII, 79110E (February 11, 2011); doi:10.1117/12.875284
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From Conference Volume 7911

  • Plasmonics in Biology and Medicine VIII
  • Tuan Vo-Dinh; Joseph R. Lakowicz
  • San Francisco, California, USA | January 22, 2011

abstract

The peak extinction wavelength of the nano-size noble metal localized surface plasmon resonance (LSPR) spectrum is unexpectedly sensitive to nanoparticle size, shape, and local external dielectric environment. This sensitivity to the environment has enabled the development of a new class of nanoscale affinity biosensors. Aptamer (single strand DNA) based gold nanorods (Au NRs) and magnetic beads (MBs) combined LSPR biosensor has been developed for the rapid and label-free detection of glycated proteins in small solution volumes. An aptamer self-assembly monolayer (SAM) functionalized surface plasmon resonance sensor has also been developed for comparison purposes. For demoonstration purposes, albumin and thrombin are used initially as the target proteins. The ability to monitor such molecules in the body could facilitate the diagnosis and treatment of diabetic patients.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Rui Zheng and Brent D. Cameron
"Aptamer-based localized surface plasmon resonance sensor for monitoring glycated proteins", Proc. SPIE 7911, Plasmonics in Biology and Medicine VIII, 79110E (February 11, 2011); doi:10.1117/12.875284; http://dx.doi.org/10.1117/12.875284


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