Application of HATR-FTIR spectroscopy to the analysis of nifedipine tablets

Cungui Cheng; Danting Li; Xinghai Liu; Jianjun Sheng; Menhai Fan; Xiaodan Li

doi:10.1117/12.666826

9 December 2005 Application of HATR-FTIR spectroscopy to the analysis of nifedipine tablets

Cungui Cheng, Danting Li, Xinghai Liu, Jianjun Sheng, Menhai Fan, Xiaodan Li

Proceedings Volume 6024, ICO20: Optical Devices and Instruments; 60240K (2005) https://doi.org/10.1117/12.666826
Event: ICO20:Optical Devices and Instruments, 2005, Changchun, China

Abstract

In recent years, FTIR has been found its wider application in analysis processes of pharmaceutical solids. This is, in part, thanks to the development of powerful multivariate quantitative techniques, such as partial least-squares (PLS) modeling software and the emergence of some new reflectance sampling techniques which allow direct measurement of the IR spectrum of solids in their native states. Horizontal Attenuated Total Reflectance (HATR) is a quite popular sampling technique in recent years. In this work, the feasibility of the Horizontal Attenuated Total Reflectance Infrared Spectroscopy (HATR-FTIR) to the quantitative and quantitative analysis of nimodipine tablets is investigated. Quantitative analysis of nimodipine is carried out by using a classical least-squares for areas procedure. Obtained from validated samples of nimodipine, quantitative results demonstrate clearly the strong potential of HATR-FTIR technique through using quantitative analysis of nimodipine content of pharmaceutical tablets.

Citation Download Citation

Cungui Cheng, Danting Li, Xinghai Liu, Jianjun Sheng, Menhai Fan, and Xiaodan Li "Application of HATR-FTIR spectroscopy to the analysis of nifedipine tablets", Proc. SPIE 6024, ICO20: Optical Devices and Instruments, 60240K (9 December 2005); https://doi.org/10.1117/12.666826

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