High-sensitive nonlinear detection of steroids by resonant double grating waveguide structures-based immunosensors

Alejandro Muriano; J.-Pablo Salvador; Roger Galve; M.-Pilar Marco; Anisha Thayil K.N.; Pablo Loza-Alvarez; Silvia Soria

doi:10.1117/12.876456

17 January 2011 High-sensitive nonlinear detection of steroids by resonant double grating waveguide structures-based immunosensors

Alejandro Muriano, J.-Pablo Salvador, Roger Galve, M.-Pilar Marco, Anisha Thayil K.N., Pablo Loza-Alvarez, Silvia Soria

Author Affiliations +

Proceedings Volume 7941, Integrated Optics: Devices, Materials, and Technologies XV; 794114 (2011) https://doi.org/10.1117/12.876456
Event: SPIE OPTO, 2011, San Francisco, California, United States

Abstract

We report the non linear fluorescence real-time detection of methylboldenone, an androgenic anabolic steroid used illegally as growth promoter based on a resonant sensing chip: a double grating waveguide structure. The limit of detection of this synthetic steroid is two orders of magnitude lower than the Minimum Required Performance Limit required by the World Anti-Doping Agency. The immunoreagents have been have been immobilized onto the surface of the resonant sensor after being activated with phosphonohexanoic acid spacers. The developed immunosensor presents great potential as a robust sensing device for fast and early detection of illegal dopants and food contaminants.

Citation Download Citation

Alejandro Muriano, J.-Pablo Salvador, Roger Galve, M.-Pilar Marco, Anisha Thayil K.N., Pablo Loza-Alvarez, and Silvia Soria "High-sensitive nonlinear detection of steroids by resonant double grating waveguide structures-based immunosensors", Proc. SPIE 7941, Integrated Optics: Devices, Materials, and Technologies XV, 794114 (17 January 2011); https://doi.org/10.1117/12.876456

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