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Proceedings Article

Chemical binding affinity estimation using MSB

[+] Author Affiliations
John B. Weaver

Dartmouth-Hitchcock Medical Ctr. (USA) and Thayer School of Engineering, Dartmouth College (USA) and Norris Cotton Cancer Ctr., Dartmouth Medical School (USA)

Adam M. Rauwerdink

Thayer School of Engineering, Dartmouth College (USA)

Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650Y (March 15, 2011); doi:10.1117/12.878788
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From Conference Volume 7965

  • Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
  • John B. Weaver; Robert C. Molthen
  • Lake Buena Vista, Florida | February 12, 2011

abstract

Binding affinity can be estimated in several ways in the laboratory but there is no viable way to estimate binding affinity in vivo without assumptions on the number of binding sites. Magnetic spectroscopy of nanoparticle Brownian motion, MSB, measures the rotational Brownian motion. The MSB signal is affected by nanoparticle binding affinity so it provides a mechanism to measure the chemical binding affinity. We present a possible mechanism to quantify the binding affinity and test that mechanism using viscous solutions.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

John B. Weaver and Adam M. Rauwerdink
"Chemical binding affinity estimation using MSB", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650Y (March 15, 2011); doi:10.1117/12.878788; http://dx.doi.org/10.1117/12.878788


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