Development of a c-scan photoacoutsic imaging probe for prostate cancer detection

Keerthi S. Valluru; Bhargava K. Chinni; Navalgund A. Rao; Shweta Bhatt; Vikram S. Dogra

doi:10.1117/12.878131

25 March 2011 Development of a c-scan photoacoutsic imaging probe for prostate cancer detection

Keerthi S. Valluru, Bhargava K. Chinni, Navalgund A. Rao, Shweta Bhatt, Vikram S. Dogra

Proceedings Volume 7968, Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy; 79680C (2011) https://doi.org/10.1117/12.878131
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

Prostate cancer is the second leading cause of death in American men after lung cancer. The current screening procedures include Digital Rectal Exam (DRE) and Prostate Specific Antigen (PSA) test, along with Transrectal Ultrasound (TRUS). All suffer from low sensitivity and specificity in detecting prostate cancer in early stages. There is a desperate need for a new imaging modality. We are developing a prototype transrectal photoacoustic imaging probe to detect prostate malignancies in vivo that promises high sensitivity and specificity. To generate photoacoustic (PA) signals, the probe utilizes a high energy 1064 nm laser that delivers light pulses onto the prostate at 10Hz with 10ns duration through a fiber optic cable. The designed system will generate focused C-scan planar images using acoustic lens technology. A 5 MHz custom fabricated ultrasound sensor array located in the image plane acquires the focused PA signals, eliminating the need for any synthetic aperture focusing. The lens and sensor array design was optimized towards this objective. For fast acquisition times, a custom built 16 channel simultaneous backend electronics PCB has been developed. It consists of a low-noise variable gain amplifier and a 16 channel ADC. Due to the unavailability of 2d ultrasound arrays, in the current implementation several B-scan (depth-resolved) data is first acquired by scanning a 1d array, which is then processed to reconstruct either 3d volumetric images or several C-scan planar images. Experimental results on excised tissue using a in-vitro prototype of this technology are presented to demonstrate the system capability in terms of resolution and sensitivity.

Citation Download Citation

Keerthi S. Valluru, Bhargava K. Chinni, Navalgund A. Rao, Shweta Bhatt, and Vikram S. Dogra "Development of a c-scan photoacoutsic imaging probe for prostate cancer detection", Proc. SPIE 7968, Medical Imaging 2011: Ultrasonic Imaging, Tomography, and Therapy, 79680C (25 March 2011); https://doi.org/10.1117/12.878131

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