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Proceedings Article

A role for Nrf2 in UVA-mediated heme oxygenase induction and protection from membrane damage in human skin fibroblasts

[+] Author Affiliations
Haibin Li, Linhao Li, Linhong Deng, Gurinder Singh, J. Li Zhong

Chongqing Univ. (China)

Rex M. Tyrrell

Univ. of Bath (United Kingdom)

Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78450X (November 08, 2010); doi:10.1117/12.870980
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From Conference Volume 7845

  • Optics in Health Care and Biomedical Optics IV
  • Qingming Luo; Ying Gu; Xingde Li
  • Beijing, China | October 18, 2010

abstract

Our previous study has shown that Ultraviolet-A (UVA) irradiation induces heme oxygenase 1 (HO-1) expression in cultured human primary skin fibroblasts FEK4. In the present study, we demonstrate a coordinated induction of HO-1 and NF-E2-related factor 2 (Nrf2) following UVA irradiation or hemin treatment. The induction of HO-1 by either UVA irradiation or hemin treatment was largely abolished by down-regulation of Nrf2 with its targeted short interfering RNA (siNrf2). The study further reveals that knockdown of Nrf2 protein increased UVA-induced cell death measured by MTS assay. These findings together indicate that Nrf2-mediated induction of HO-1 expression may provide a cytoprotection for human skin cells from oxidative damage.

© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Topics

Skin
Citation

Haibin Li ; Linhao Li ; Linhong Deng ; Gurinder Singh ; Rex M. Tyrrell, et al.
"A role for Nrf2 in UVA-mediated heme oxygenase induction and protection from membrane damage in human skin fibroblasts", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78450X (November 08, 2010); doi:10.1117/12.870980; http://dx.doi.org/10.1117/12.870980


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