Steroid-induced osteoporosis monitored by Raman spectroscopy

Jason R. Maher; Masahiko Takahata; Hani A. Awad; Andrew J. Berger

doi:10.1117/12.873953

18 February 2011 Steroid-induced osteoporosis monitored by Raman spectroscopy

Jason R. Maher, Masahiko Takahata, Hani A. Awad, Andrew J. Berger

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78834H (2011) https://doi.org/10.1117/12.873953
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Glucocorticoids are frequently used to treat inflammatory disorders such as rheumatoid arthritis. Unfortunately, extended exposure to this steroid is the leading cause of physician-induced osteoporosis, leaving patients susceptible to fractures at rates of 30-50%. In this presentation, we report correlations between Raman spectra and biomechanical strength tests on bones of glucocorticoid- and placebo- treated mice. Both wild-type mice and a transgenic model of rheumatoid arthritis have been studied. A two-way ANOVA model reveals statistically significant spectral differences as influenced by glucocorticoid treatment and mouse type.

Citation Download Citation

Jason R. Maher, Masahiko Takahata, Hani A. Awad, and Andrew J. Berger "Steroid-induced osteoporosis monitored by Raman spectroscopy", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834H (18 February 2011); https://doi.org/10.1117/12.873953

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available