Effect of timolol on sub-foveal choroidal blood flow using laser Doppler flowmetry

Nithiyanantham Palanisamy; Luigi Rovati; Mauro Cellini; Corrado Gizzi; Ernesto Strobbe; Emilio Campos; Charles E. Riva

doi:10.1117/12.874495

11 February 2011 Effect of timolol on sub-foveal choroidal blood flow using laser Doppler flowmetry

Nithiyanantham Palanisamy, Luigi Rovati, Mauro Cellini, Corrado Gizzi, Ernesto Strobbe, Emilio Campos, Charles E. Riva

Proceedings Volume 7885, Ophthalmic Technologies XXI; 78850E (2011) https://doi.org/10.1117/12.874495
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Laser Doppler flowmetry (LDF) is a technique used to measure relative average velocity, number and flux (number times velocity) of red blood cells in vessels or capillaries. In this study, the effect of topical timolol on the choroidal circulation was investigated in 12 healthy subjects. Maximum velocity of red blood cells and volumetric blood flow rate in sub-foveal choroids are determined in each eye just before instillation of drops and then every 30 min upto 2 hours. Average intraocular pressure (IOP) decreased significantly in the timolol-treated eyes compared to that of placebo-treated eyes. Nevertheless no significant differences in choroidal blood hemodynamic between timolol and placebo-treated eyes were observed.

Citation Download Citation

Nithiyanantham Palanisamy, Luigi Rovati, Mauro Cellini, Corrado Gizzi, Ernesto Strobbe, Emilio Campos, and Charles E. Riva "Effect of timolol on sub-foveal choroidal blood flow using laser Doppler flowmetry", Proc. SPIE 7885, Ophthalmic Technologies XXI, 78850E (11 February 2011); https://doi.org/10.1117/12.874495

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