Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography

Hrebesh M. Subhash; Viviana Davila; Hai Sun; Anh T. Nguyen-Huynh; Alfred L. Nuttall; Ruikang K. Wang

doi:10.1117/12.874182

11 February 2011 Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography

Hrebesh M. Subhash, Viviana Davila, Hai Sun, Anh T. Nguyen-Huynh, Alfred L. Nuttall, Ruikang K. Wang

Author Affiliations +

Proceedings Volume 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV; 78892V (2011) https://doi.org/10.1117/12.874182
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Studying the inner ear microstructures and microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention and treatment of many otologic disorders. There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea and the micro vascular perfusion within it for both clinical as well as fundamental studies. In this study, we explored the feasibility of high-speed spectral domain optical coherence tomography (SD-OCT) and ultra-high sensitive optical microangiography (UHS-OMAG) for volumetric in vivo imaging of intracochlear microstructures and microvascular perfusion in mice, respectively.

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Hrebesh M. Subhash, Viviana Davila, Hai Sun, Anh T. Nguyen-Huynh, Alfred L. Nuttall, and Ruikang K. Wang "Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography", Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 78892V (11 February 2011); https://doi.org/10.1117/12.874182

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KEYWORDS

In vivo imaging

Optical coherence tomography

3D image processing

Ear

Tissue optics

3D image reconstruction

Imaging systems

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