Label-free 3D optical imaging of microcirculation within sentinel lymph node in vivo

Yeongri Jung; Zhongwei Zhi; Ruikang K. Wang

doi:10.1117/12.875682

11 February 2011 Label-free 3D optical imaging of microcirculation within sentinel lymph node in vivo

Yeongri Jung, Zhongwei Zhi, Ruikang K. Wang

Proceedings Volume 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV; 788910 (2011) https://doi.org/10.1117/12.875682
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Sentinel lymph node (SLN) is the first lymph node to drain wastes originated from cancerous tissue. There is a need for an in vivo imaging method that can image the intact SLN in order to further our understanding of its normal as well as abnormal functions. We report the use of ultrahigh sensitive optical microangiography (UHS-OMAG) to image functional microvascular and lymphatic vessel networks that innervate the intact lymph node in mice in vivo. The promising results show a potential role of UHS-OMAG in the future understanding and diagnosis of the SLN involvement in cancer development.

Citation Download Citation

Yeongri Jung, Zhongwei Zhi, and Ruikang K. Wang "Label-free 3D optical imaging of microcirculation within sentinel lymph node in vivo", Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 788910 (11 February 2011); https://doi.org/10.1117/12.875682

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KEYWORDS

Lymphatic system

In vivo imaging

3D image processing

Tissue optics

Cancer

Optical coherence tomography

Optical imaging

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