Image contrast in fluorescence and magnetic resonance images for glioblastoma detection

Kimberley S. Samkoe; Summer L. Gibbs-Strauss; Harold H. Yang; S. Khan Hekmatyar; P. Jack Hoopes; Julia A. O'Hara; Risto A. Kauppinen; Brian W. Pogue

doi:10.1117/12.875425

10 February 2011 Image contrast in fluorescence and magnetic resonance images for glioblastoma detection

Kimberley S. Samkoe, Summer L. Gibbs-Strauss, Harold H. Yang, S. Khan Hekmatyar, P. Jack Hoopes, Julia A. O'Hara, Risto A. Kauppinen, Brian W. Pogue

Author Affiliations +

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920O (2011) https://doi.org/10.1117/12.875425
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A diffusely infiltrative human glioma cell line (U251-GFP) has been developed and used as a model for the tumor growth outside of MR image detectable tumor boundary. The aminolevulinic acid-protoporphyrin IX (ALA-PpIX) fluorescence system has shown great strides for fluorescence guided surgical resection, but often fluorescence is observed outside of the MR image detectable tumor margin. Here we compare the use of ALA-PpIX fluorescence with that of standard gadolinium enhanced MR imaging as well as T2 and diffusion imaging to determine whether there is a correlation between fluorescence and MR imaging. We found that PpIX fluorescence, T1WCD and Absolute T2 images have the highest contrast difference from controls and are likely candidates for highly infiltrative tumor detection.

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Kimberley S. Samkoe, Summer L. Gibbs-Strauss, Harold H. Yang, S. Khan Hekmatyar, P. Jack Hoopes, Julia A. O'Hara, Risto A. Kauppinen, and Brian W. Pogue "Image contrast in fluorescence and magnetic resonance images for glioblastoma detection", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920O (10 February 2011); https://doi.org/10.1117/12.875425

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