An investigation on fluorescent-optical dual-mode tomography using time-resolved data

Limin Zhang; Wei Zhang; Feng Gao; Jiao Li; Huijuan Zhao

doi:10.1117/12.873361

21 February 2011 An investigation on fluorescent-optical dual-mode tomography using time-resolved data

Limin Zhang, Wei Zhang, Feng Gao, Jiao Li, Huijuan Zhao

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920Q (2011) https://doi.org/10.1117/12.873361
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We present a scheme for fluorescence guided diffusion optical tomography to reconstruct the fluorescence parameters (yield and lifetime) and optical parameters (absorption and reduced coefficients) based on time-resolved data. In this paper, the fluorescence parameters were reconstructed at first, then the fluorescence images were used to guide and constrain the diffusion optical tomography reconstruction, and the binary image segmentation strategy was applied to improve the image quality in DOT. To validate the proposed method, the numerical simulation was performed to demonstrate its computational efficacy. The results showed the feasibility of this method, and the spatial resolution, quantification and computational efficiency in DOT were enhanced evidently.

Citation Download Citation

Limin Zhang, Wei Zhang, Feng Gao, Jiao Li, and Huijuan Zhao "An investigation on fluorescent-optical dual-mode tomography using time-resolved data", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920Q (21 February 2011); https://doi.org/10.1117/12.873361

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