Integrated scanning laser ophthalmoscopy and optical coherence tomography for quantitative multimodal imaging of retinal degeneration and autofluorescence

Ali Issaei; Lukasz Szczygiel; Nima Hossein-Javaheri; Mei Young; L. L. Molday; R. S. Molday; M. V. Sarunic

doi:10.1117/12.873982

10 February 2011 Integrated scanning laser ophthalmoscopy and optical coherence tomography for quantitative multimodal imaging of retinal degeneration and autofluorescence

Ali Issaei, Lukasz Szczygiel, Nima Hossein-Javaheri, Mei Young, L. L. Molday, R. S. Molday, M. V. Sarunic

Author Affiliations +

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 789209 (2011) https://doi.org/10.1117/12.873982
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Scanning Laser Ophthalmoscopy (SLO) and Coherence Tomography (OCT) are complimentary retinal imaging modalities. Integration of SLO and OCT allows for both fluorescent detection and depth- resolved structural imaging of the retinal cell layers to be performed in-vivo. System customization is required to image rodents used in medical research by vision scientists. We are investigating multimodal SLO/OCT imaging of a rodent model of Stargardt's Macular Dystrophy which is characterized by retinal degeneration and accumulation of toxic autofluorescent lipofuscin deposits. Our new findings demonstrate the ability to track fundus autofluorescence and retinal degeneration concurrently.

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Ali Issaei, Lukasz Szczygiel, Nima Hossein-Javaheri, Mei Young, L. L. Molday, R. S. Molday, and M. V. Sarunic "Integrated scanning laser ophthalmoscopy and optical coherence tomography for quantitative multimodal imaging of retinal degeneration and autofluorescence", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 789209 (10 February 2011); https://doi.org/10.1117/12.873982

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