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Proceedings Article

Multi-site and multi-depth in vivo cancer localization enhancement after autofluorescence removal

[+] Author Affiliations
Anne-Sophie Montcuquet

CEA, LETI, MINATEC (France) and GIPSA-Lab., DIS (France)

Lionel Hervé, Fabrice Navarro, Jean-Marc Dinten

CEA, LETI, MINATEC (France)

Jérôme I. Mars

GIPSA-Lab., DIS (France)

Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962S (February 17, 2011); doi:10.1117/12.874594
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From Conference Volume 7896

  • Optical Tomography and Spectroscopy of Tissue IX
  • Bruce J. Tromberg; Arjun G. Yodh; Mamoru Tamura; Eva M. Sevick-Muraca; Robert R. Alfano
  • San Francisco, California, USA | January 22, 2011

abstract

Fluorescence imaging in diffusive media locates tumors tagged by injected fluorescent markers in NIR wave-lengths. For deep embedded markers, natural autofluorescence of tissues comes to be a limiting factor to tumor detection and accurate FDOT reconstructions. A spectroscopic approach coupled with Non-negative Matrix Factorization source separation method is explored to discriminate fluorescence sources according to their fluorescence spectra and remove unwanted autofluorescence. We successfully removed autofluorescence from acquisitions on living mice with a single subcutaneous tumor or two capillary tubes inserted at different depths.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Anne-Sophie Montcuquet ; Lionel Hervé ; Fabrice Navarro ; Jean-Marc Dinten and Jérôme I. Mars
"Multi-site and multi-depth in vivo cancer localization enhancement after autofluorescence removal", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962S (February 17, 2011); doi:10.1117/12.874594; http://dx.doi.org/10.1117/12.874594


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