Detecting lower extremity vascular dynamics in patients with peripheral artery disease using diffuse optical tomography

Michael A. Khalil; Hyun-Keol K. Kim; In-Kyong Kim; Rajeev Dayal; Andreas H. Hielscher

doi:10.1117/12.874236

17 February 2011 Detecting lower extremity vascular dynamics in patients with peripheral artery disease using diffuse optical tomography

Michael A. Khalil, Hyun-Keol K. Kim, In-Kyong Kim, Rajeev Dayal, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78962Z (2011) https://doi.org/10.1117/12.874236
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Peripheral Artery Disease (PAD) affects over 10 million Americans and is associated with significant morbidity and mortality. While in many cases the ankle-brachial index (ABI) can be used for diagnosing the disease, this parameter is not dependable in the diabetic and elderly population. These populations tend to have calcified arteries, which leads to elevated ABI values. Dynamic optical tomography (DDOT) promises to overcome the limitations of the current diagnostic techniques and has the potential to initiate a paradigm shift in the diagnosis of vascular disease. We have performed initial pilot studies involving 5 PAD patients and 3 healthy volunteers. The time traces and tomographic reconstruction obtained from measurements on the feet show significant differences between healthy and affected vasculatures. In addition, we found that DOT is capable of identifying PAD in diabetic patients, who are misdiagnosed by the traditional ABI screening.

Citation Download Citation

Michael A. Khalil, Hyun-Keol K. Kim, In-Kyong Kim, Rajeev Dayal, and Andreas H. Hielscher "Detecting lower extremity vascular dynamics in patients with peripheral artery disease using diffuse optical tomography", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962Z (17 February 2011); https://doi.org/10.1117/12.874236

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