Characterization of 2D surface imaging of tissue optical properties using a sub-millimeter fiber optic probe

Vikrant Sharma; Hanli Liu

doi:10.1117/12.875394

17 February 2011 Characterization of 2D surface imaging of tissue optical properties using a sub-millimeter fiber optic probe

Vikrant Sharma, Hanli Liu

Author Affiliations +

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 789636 (2011) https://doi.org/10.1117/12.875394
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Broad-band light reflectance spectroscopy (LRS) of tissue with sub-millimeter fiber optic probes in the visible and nearinfrared range has shown its utility in differentiation of tissue types, identification of cancer, and measurement of stimulus-induced physiological responses. So far, single point measurement set-up has been widely employed to determine local optical properties of tissue. However, it may often be of interest to obtain a 2D map of a surface area of a tissue under investigation, rather than a single point reading, as in case of cancer margin detection or intraoperative perfusion measurement. It is thus imperative to expand the LRS technique to multipoint measurement covering a larger surface area. Here we describe the two methods that we use to quantify the hemoglobin derivatives and scattering of tissue under investigation, and then utilize two bifurcated fiber optic probes with different fiber diameters and different source-detector separations, to demonstrate the 2D imaging capability of LRS technique. In this study, we constructed a tissue phantom, simulating tissue and blood vessel, and used 2D scanning to determine the spatial resolution and depth resolution using two different probe geometries. Our results suggest that the depth sensitivity of these probes was limited to sub-millimeter for hemoglobin derivatives, whereas scattering changes could be observed up to 2mm deep. It was also found that the lateral resolution was affected, and the scattering signal became more diffuse, as a function of depth.

Citation Download Citation

Vikrant Sharma and Hanli Liu "Characterization of 2D surface imaging of tissue optical properties using a sub-millimeter fiber optic probe", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789636 (17 February 2011); https://doi.org/10.1117/12.875394

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tissue optics

Tissues

Lawrencium

Scattering

Solids

Natural surfaces

Optical properties

Show All Keywords

Keywords/Phrases

Search In:

Publication Years