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Proceedings Article

Optical control of urinary bladder contraction using femtosecond-pulsed laser

[+] Author Affiliations
Jonghee Yoon, Myunghwan Choi, Chulhee Choi

KAIST (Korea, Republic of)

Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 789714 (February 18, 2011); doi:10.1117/12.874022
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From Conference Volume 7897

  • Optical Interactions with Tissue and Cells XXII
  • E. Duco Jansen; Robert J. Thomas
  • San Francisco, California, USA | January 22, 2011

abstract

Even though catheterization or electric stimulation are used for treatment of neurogenic bladder, invasiveness and inconvenience of these approaches prompt us to develop a new possible therapeutic method to control urination by using optical stimulation. The optical method using femtosecond pulsed laser (FSPL) has advantages of focused and subsurface stimulation. Irradiation of FSPL induced a rapid increase of intracellular calcium level followed by contraction of primary cultured human bladder smooth muscle cells. Short exposure of bladder detrusor ex-vivo to FSPL also induced a controlled contraction of detrusor. Collectively, we propose that FSPL can be considered as a potential therapeutic approach for intractable neurogenic bladder.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Jonghee Yoon ; Myunghwan Choi and Chulhee Choi
"Optical control of urinary bladder contraction using femtosecond-pulsed laser", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 789714 (February 18, 2011); doi:10.1117/12.874022; http://dx.doi.org/10.1117/12.874022


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