Development of an absorption-based tomographic system for mapping the human microvasculature

Paul M. McNamara; Enock Jonathan; Martin J. Leahy

doi:10.1117/12.880047

10 February 2011 Development of an absorption-based tomographic system for mapping the human microvasculature

Paul M. McNamara, Enock Jonathan, Martin J. Leahy

Proceedings Volume 7898, Dynamics and Fluctuations in Biomedical Photonics VIII; 78980N (2011) https://doi.org/10.1117/12.880047
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

There exist numerous planar imaging methods for mapping the human microvasculature. In medical diagnostics, tomography is preferred over surface imaging for the simple reason that biological organs are 3-dimensional in nature. The aim of this work is to create a novel technique to non-invasively map the concentration of red blood cells in the human microcirculation allowing 3-dimensional image reconstruction. We propose a tomographic system which is based on absorption contrast imaging. A Michelson interferometry method is employed using a broadband, white light source. This work details preliminary results of the calibration procedure of a 'bulk' system. A mirror, reflectance standards, glass-mirror arrangement, and color filter arrangement were used as samples. The resultant interference patterns from each were imaged and analyzed.

Citation Download Citation

Paul M. McNamara, Enock Jonathan, and Martin J. Leahy "Development of an absorption-based tomographic system for mapping the human microvasculature", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 78980N (10 February 2011); https://doi.org/10.1117/12.880047

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