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Proceedings Article

Optical-resolution photoacoustic microscopy of ischemic stroke

[+] Author Affiliations
Song Hu, Brian Soetikno, Enhao Gong, Konstantin Maslov, Lihong V. Wang

Washington Univ. in St. Louis (USA)

Ernie Gonzales, Ping Yan, Jin-Moo Lee

Washington Univ. School of Medicine (USA)

Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789906 (February 10, 2011); doi:10.1117/12.874366
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From Conference Volume 7899

  • Photons Plus Ultrasound: Imaging and Sensing 2011
  • Alexander A. Oraevsky; Lihong V. Wang
  • San Francisco, California, USA | January 22, 2011

abstract

A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO2) values of feeder arteries and draining veins within the stroke core region dropped ~10% and ~34%, respectively. After reperfusion, arterial sO2 recovered back to the baseline; however, the venous sO2 increased above the baseline value by ~7%. Thereafter, venous sO2 values were close to the arterial sO2 values, suggesting eventual brain tissue infarction.

© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation

Song Hu ; Ernie Gonzales ; Brian Soetikno ; Enhao Gong ; Ping Yan, et al.
"Optical-resolution photoacoustic microscopy of ischemic stroke", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789906 (February 10, 2011); doi:10.1117/12.874366; http://dx.doi.org/10.1117/12.874366


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