Full-field, nonscanning, optical imaging for perfusion indication

Nee-Yin Chou; L. W. Winchester Jr.; W. J. Naramore; M. S. Alley; A. J. Lesnick

doi:10.1117/12.855071

12 April 2010 Full-field, nonscanning, optical imaging for perfusion indication

Nee-Yin Chou, L. W. Winchester Jr., W. J. Naramore, M. S. Alley, A. J. Lesnick

Proceedings Volume 7703, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII; 77030S (2010) https://doi.org/10.1117/12.855071
Event: SPIE Defense, Security, and Sensing, 2010, Orlando, Florida, United States

Abstract

Laser speckle imaging (LSI) has been gaining popularity for the past few years. Like other optical imaging modalities such as optical coherence tomography (OCT), orthogonal polarization spectroscopy (OPS), and laser Doppler imaging (LDI), LSI utilizes nonionizing radiation. In LSI, blood flow velocity is obtained by analyzing, temporally or spatially, laser speckle (LS) patterns generated when an expanded laser beam illuminates the tissue. The advantages of LSI are that it is fast, does not require scanning, and provides full-field LS images to extract realtime, quantitative hemodynamic information of subtle changes in the tissue vasculature. For medical applications, LSI has been used for obtaining blood velocities in human retina, skin flaps, wounds, and cerebral and sublingual areas. When coupled with optical fibers, LSI can be used for endoscopic measurements for a variety of applications. This paper describes the application of LSI in retinal, sublingual, and skin flap measurements. Evaluation of retinal hemodynamics provides very important diagnostic information, since the human retina offers direct optical access to both the central nervous system (CNS) and afferent and efferent CNS vasculature. The performance of an LSI-based fundus imager for measuring retinal hemodynamics is presented. Sublingual microcirculation may have utility for sepsis indication, since inherent in organ injury caused by sepsis is a profound change in microvascular hemodynamics. Sublingual measurement results using an LSI scope are reported. A wound imager for imaging LS patterns of wounds and skin flaps is described, and results are presented.

Citation Download Citation

Nee-Yin Chou, L. W. Winchester Jr., W. J. Naramore, M. S. Alley, and A. J. Lesnick "Full-field, nonscanning, optical imaging for perfusion indication", Proc. SPIE 7703, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII, 77030S (12 April 2010); https://doi.org/10.1117/12.855071

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KEYWORDS

Blood

Oxygen

Imaging systems

Temperature metrology

Blood circulation

Tissues

Speckle

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