Directional assessment of fiber integrity in Q-ball imaging

Klaus H. Fritzsche; Frederik B. Laun; Bram Stieltjes; Hans-Peter Meinzer

doi:10.1117/12.839608

12 March 2010 Directional assessment of fiber integrity in Q-ball imaging

Klaus H. Fritzsche, Frederik B. Laun, Bram Stieltjes, Hans-Peter Meinzer

Proceedings Volume 7623, Medical Imaging 2010: Image Processing; 76231G (2010) https://doi.org/10.1117/12.839608
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

Q-ball imaging (QBI) is a diffusion imaging technique that provides unique microstructural information and outperforms diffusion tensor imaging (DTI) in areas of fiber crossings. The generalized fractional anisotropy (GFA) is a widely accepted quantitative measure of fiber integrity for QBI. In this paper we demonstrate a major drawback of the GFA occuring in crossing fiber regions: the fiber integrity is heavily underestimated here. We present a new, directional anisotropy measure and compare it to the GFA using custom-designed fiber phantoms and Monte Carlo simulations. Furthermore, we present in-vivo data of the measure. With the expense of reduced CNR, the new measure allows a better quantification of fiber bundles in crossing regions and potentially yields additional information regarding non-dominant tracts within a voxel.

Citation Download Citation

Klaus H. Fritzsche, Frederik B. Laun, Bram Stieltjes, and Hans-Peter Meinzer "Directional assessment of fiber integrity in Q-ball imaging", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 76231G (12 March 2010); https://doi.org/10.1117/12.839608

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