Tissue volume and vesselness measure preserving nonrigid registration of lung CT images

Kunlin Cao; Kai Ding; Gary E. Christensen; Joseph M. Reinhardt

doi:10.1117/12.844541

12 March 2010 Tissue volume and vesselness measure preserving nonrigid registration of lung CT images

Kunlin Cao, Kai Ding, Gary E. Christensen, Joseph M. Reinhardt

Proceedings Volume 7623, Medical Imaging 2010: Image Processing; 762309 (2010) https://doi.org/10.1117/12.844541
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

In registration-based analyses of lung biomechanics and function, high quality registrations are essential to obtain meaningful results. Various criteria have been suggested to find the correspondence mappings between two lung images acquired at different levels of inflation. In this paper, we describe a new metric, the sum of squared vesselness measure difference (SSVMD), that utilizes the rich information of blood vessel locations and matches similar vesselness patterns in two images. Preserving both the lung tissue volume and the vesselness measure, a registration algorithm is developed to minimize the sum of squared tissue volume difference (SSTVD) and SSVMD together. We compare the registration accuracy using SSTVD + SSVMD with that using SSTVD alone by registering lung CT images of three normal human subjects. After adding the new SSVMD metric, the improvement of registration accuracy is observed by landmark error and fissure positioning error analyses. The average values of landmark error and fissure positioning error are reduced by about 30% and 25%, respectively. The mean landmark error is on the order of 1 mm. Statistical testing of landmark errors shows that there is a statistically significant difference between two methods with p values < 0.05 in all three subjects. Visual inspection shows there are obvious accuracy improvements in the lung regions near the thoracic cage after adding SSVMD.

Citation Download Citation

Kunlin Cao, Kai Ding, Gary E. Christensen, and Joseph M. Reinhardt "Tissue volume and vesselness measure preserving nonrigid registration of lung CT images", Proc. SPIE 7623, Medical Imaging 2010: Image Processing, 762309 (12 March 2010); https://doi.org/10.1117/12.844541

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available