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Proceedings Article

Volumetric breast density evaluation by ultrasound tomography and magnetic resonance imaging: a preliminary comparative study

[+] Author Affiliations
Lukasz Myc, Neb Duric, Peter Littrup, Cuiping Li, Bryan Ranger, Jessica Lupinacci, Steven Schmidt, Olsi Rama, Lisa Bey-Knight

Karmanos Cancer Institute, Wayne State Univ. (USA)

Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 76290N (March 12, 2010); doi:10.1117/12.845648
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From Conference Volume 7629

  • Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy
  • Jan D'hooge; Stephen A. McAleavey
  • San Diego, California, United States | February 13, 2010

abstract

Since a 1976 study by Wolfe, high breast density has gained recognition as a factor strongly correlating with an increased incidence of breast cancer. These observations have led to mammographic density being designated a "risk factor" for breast cancer. Clinically, the exclusive reliance on mammography for breast density measurement has forestalled the inclusion of breast density into statistical risk models. This exclusion has in large part been due to the ionizing radiation associated with the method. Additionally, the use of mammography as valid tool for measuring a three dimensional characteristic (breast density) has been criticized for its prima facie incongruity. These shortfalls have prompted MRI studies of breast density as an alternative three-dimensional method of assessing breast density. Although, MRI is safe and can be used to measure volumetric density, its cost has prohibited its use in screening. Here, we report that sound speed measurements using a prototype ultrasound tomography device have potential for use as surrogates for breast density measurement. Accordingly, we report a strong positive linear correlation between volume-averaged sound speed of the breast and percent glandular tissue volume as assessed by MR.

© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Lukasz Myc ; Neb Duric ; Peter Littrup ; Cuiping Li ; Bryan Ranger, et al.
"Volumetric breast density evaluation by ultrasound tomography and magnetic resonance imaging: a preliminary comparative study", Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 76290N (March 12, 2010); doi:10.1117/12.845648; http://dx.doi.org/10.1117/12.845648


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