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Proceedings Article

Registration of x-ray mammograms and three-dimensional speed of sound images of the female breast

[+] Author Affiliations
Torsten Hopp, Marie Holzapfel, Nicole V. Ruiter

Karlsruhe Institute of Technology (Germany)

Cuiping Li, Neb Duric

Karmanos Cancer Institute (USA)

Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 762905 (March 11, 2010); doi:10.1117/12.843454
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From Conference Volume 7629

  • Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy
  • Jan D'hooge; Stephen A. McAleavey
  • San Diego, California, United States | February 13, 2010

abstract

Breast cancer is the most common type of cancer among women in Europe and North America. The established screening method to detect breast cancer is X-ray mammography, although X-ray frequently provides poor contrast for tumors located within glandular tissue. A new imaging approach is Ultrasound Tomography generating three-dimensional speed of sound images. This paper describes a method to evaluate the clinical applicability of three-dimensional speed of sound images by automatically registering the images with the corresponding X-ray mammograms. The challenge is that X-ray mammograms show two-dimensional projections of a deformed breast whereas speed of sound images render a three-dimensional undeformed breast in prone position. This conflict requires estimating the relation between deformed and undeformed breast and applying the deformation to the three-dimensional speed of sound image. The deformation is simulated based on a biomechanical model using the finite element method. After simulation of the compression, the contours of the X-ray mammogram and the projected speed of sound image overlap congruently. The quality of the matching process was evaluated by measuring the overlap of a lesion marked in both modalities. Using four test datasets, the evaluation of the registration resulted in an average tumor overlap of 97%. The developed registration provides a basis for systematic evaluation of the new modality of three-dimensional speed of sound images, e.g. allows a greater understanding of tumor depiction in these new images.

© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Torsten Hopp ; Marie Holzapfel ; Nicole V. Ruiter ; Cuiping Li and Neb Duric
"Registration of x-ray mammograms and three-dimensional speed of sound images of the female breast", Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 762905 (March 11, 2010); doi:10.1117/12.843454; http://dx.doi.org/10.1117/12.843454


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