Breast imaging with ultrasound tomography: a comparative study with MRI

Bryan Ranger; Peter Littrup; Neb Duric; Cuiping Li; Steven Schmidt; Jessica Lupinacci; Lukasz Myc; Amy Szczepanski; Olsi Rama; Lisa Bey-Knight

doi:10.1117/12.845650

12 March 2010 Breast imaging with ultrasound tomography: a comparative study with MRI

Bryan Ranger, Peter Littrup, Neb Duric, Cuiping Li, Steven Schmidt, Jessica Lupinacci, Lukasz Myc, Amy Szczepanski, Olsi Rama, Lisa Bey-Knight

Author Affiliations +

Proceedings Volume 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy; 762906 (2010) https://doi.org/10.1117/12.845650
Event: SPIE Medical Imaging, 2010, San Diego, California, United States

Abstract

The purpose of this study was to investigate the performance of an ultrasound tomography (UST) prototype relative to magnetic resonance (MR) for imaging overall breast anatomy and accentuating tumors relative to background tissue. The study was HIPAA compliant, approved by the Institutional Review Board, and performed after obtaining the requisite informed consent. Twenty-three patients were imaged with MR and the UST prototype. T₁ weighted images with fat saturation, with and without gadolinium enhancement, were used to examine anatomical structures and tumors, while T₂ weighted images were used to identify cysts. The UST scans generated sound speed, attenuation, and reflection images. A qualitative visual comparison of the MRI and UST images was then used to identify anatomical similarities. A more focused approach that involved a comparison of reported masses, lesion volumes, and breast density was used to quantify the findings from the visual assessment. Our acoustic tomography prototype imaged distributions of fibrous stroma, parenchyma, fatty tissues, and lesions in patterns similar to those seen in the MR images. The range of thresholds required to establish tumor volume equivalency between MRI and UST suggested that a universal threshold for isolating masses relative to background tissue is feasible with UST. UST has demonstrated the ability to visualize and characterize breast tissues in a manner comparable to MRI. Thresholding techniques accentuate masses relative to background anatomy, which may prove clinically useful for early cancer detection.

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Bryan Ranger, Peter Littrup, Neb Duric, Cuiping Li, Steven Schmidt, Jessica Lupinacci, Lukasz Myc, Amy Szczepanski, Olsi Rama, and Lisa Bey-Knight "Breast imaging with ultrasound tomography: a comparative study with MRI", Proc. SPIE 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy, 762906 (12 March 2010); https://doi.org/10.1117/12.845650

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