Coherent anti-stokes Raman scattering (RP-CARS) microscopy for sensing molecular orientations

Wei Zheng; Zhiwei Huang

doi:10.1117/12.854965

25 November 2009 Coherent anti-stokes Raman scattering (RP-CARS) microscopy for sensing molecular orientations

Wei Zheng, Zhiwei Huang

Proceedings Volume 7634, Optical Sensors and Biophotonics; 76340V (2009) https://doi.org/10.1117/12.854965
Event: Asia Communications and Photonics, 2009, Shanghai, Shanghai , China

Abstract

We report coherent anti-Stokes Raman scattering (CARS) microscopy with radially polarized (RP) excitation for facilitating longitudinally oriented molecules detection. Our finite-difference time-domain (FDTD) simulation results show that the maximum near-field RP-CARS radiation from the two longitudinally orientated nanoparticles is around 1.3 times higher than that from transversely orientated nanoparticles. Our further CARS experiments show that RP-CARS radiation from molecules oriented along the longitudinal direction is approximately 3-fold stronger than that using linearly polarized CARS technique, and the lateral resolution of RP-CARS imaging can be improved by about 10% compared to the linearly polarized CARS imaging.

Citation Download Citation

Wei Zheng and Zhiwei Huang "Coherent anti-stokes Raman scattering (RP-CARS) microscopy for sensing molecular orientations", Proc. SPIE 7634, Optical Sensors and Biophotonics, 76340V (25 November 2009); https://doi.org/10.1117/12.854965

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