Targeted in-vivo computed tomography (CT) imaging of tissue ACE using concentrated lisinopril-capped gold nanoparticle solutions

Marie-Christine Daniel; Omer Aras; Mark F. Smith; Anjan Nan; Thorsten Fleiter

doi:10.1117/12.849841

23 April 2010 Targeted in-vivo computed tomography (CT) imaging of tissue ACE using concentrated lisinopril-capped gold nanoparticle solutions

Marie-Christine Daniel, Omer Aras, Mark F. Smith, Anjan Nan, Thorsten Fleiter

Author Affiliations +

Proceedings Volume 7674, Smart Biomedical and Physiological Sensor Technologies VII; 76740J (2010) https://doi.org/10.1117/12.849841
Event: SPIE Defense, Security, and Sensing, 2010, Orlando, Florida, United States

Abstract

The development of cardiac and pulmonary fibrosis have been associated with overexpression of angiotensin-converting enzyme (ACE). Moreover, ACE inhibitors, such as lisinopril, have shown a benificial effect for patients diagnosed with heart failure or systemic hypertension. Thus targeted imaging of the ACE is of crucial importance for monitoring of the tissue ACE activity as well as the treatment efficacy in heart failure. In this respect, lisinopril-capped gold nanoparticles were prepared to provide a new type of probe for targeted molecular imaging of ACE by tuned K-edge computed tomography (CT) imaging. Concentrated solutions of these modified gold nanoparticles, with a diameter around 16 nm, showed high contrast in CT imaging. These new targeted imaging agents were thus used for in vivo imaging on rat models.

Citation Download Citation

Marie-Christine Daniel, Omer Aras, Mark F. Smith, Anjan Nan, and Thorsten Fleiter "Targeted in-vivo computed tomography (CT) imaging of tissue ACE using concentrated lisinopril-capped gold nanoparticle solutions", Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 76740J (23 April 2010); https://doi.org/10.1117/12.849841

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available