Effect of thickness of the superficial tissues on the spatial sensitivity profile for optical imaging

Eiji Okada

doi:10.1117/12.500389

15 October 2003 Effect of thickness of the superficial tissues on the sensitivity profile for optical imaging

Eiji Okada

Proceedings Volume 5138, Photon Migration and Diffuse-Light Imaging; (2003) https://doi.org/10.1117/12.500389
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

It is important for near-infrared imaging to estimate the sensitivity of detected signal to the change in absorption of tissue resulting from brain activation and the volume of tissue interrogated for a specific source-detector spacing. In this study, light propagation in adult head models is predicted by Monte Carlo simulation in order to investigate the effect of the thickness of the superficial tissues on the partial optical path length in the brain and on the spatial sensitivity profile. The effect of thickness of skull on the partial optical path length and spatial sensitivity profile is almost the same as that of the scalp. The effect of thickness of cerebrospinal fluid layer on the partial optical path length and spatial sensitivity profile is different from that of the scalp and skull. The partial optical path length mainly depends upon the depth of inner skull surface whilst the spatial sensitivity profile is considerably affected by the thickness of the cerebrospinal fluid layer.

Citation Download Citation

Eiji Okada "Effect of thickness of the superficial tissues on the sensitivity profile for optical imaging", Proc. SPIE 5138, Photon Migration and Diffuse-Light Imaging, (15 October 2003); https://doi.org/10.1117/12.500389

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KEYWORDS

Skull

Brain

Head

Tissues

Geometrical optics

Near infrared

Tissue optics

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