Fluorescence spectroscopy and imaging for noninvasive diagnostics: applications to early cancer detection in the lung

Mary-Ann Mycek; Paul Urayama; Wei Zhong; Roger D. Sloboda; Konstantin H. Dragnev; Ethan Dmitrovsky

doi:10.1117/12.499867

8 October 2003 Fluorescence spectroscopy and imaging for noninvasive diagnostics: applications to early cancer detection in the lung

Mary-Ann Mycek, Paul Urayama, Wei Zhong, Roger D. Sloboda, Konstantin H. Dragnev, Ethan Dmitrovsky

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Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.499867
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Tissue fluorescence spectroscopy and imaging are being investigated as potential methods for non-invasive detection of pre-neoplastic change in the lung and other organ systems. A substantial contribution to tissue fluorescence is known to arise from endogenous cellular fluorophores. Using steady-state and time-resolved fluorescence spectroscopy and imaging, we characterized the endogenous fluorescence properties of immortalized and carcinogen-transformed human bronchial epithelial cells. Non-invasive sensing of endogenous molecular biomarkers associated with human bronchial pre-neoplasia will be discussed.

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Mary-Ann Mycek, Paul Urayama, Wei Zhong, Roger D. Sloboda, Konstantin H. Dragnev, and Ethan Dmitrovsky "Fluorescence spectroscopy and imaging for noninvasive diagnostics: applications to early cancer detection in the lung", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.499867

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KEYWORDS

Luminescence

Imaging spectroscopy

Oxygen

Fluorescence lifetime imaging

Imaging systems

Fluorescence spectroscopy

Tissues

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