Detection of explosives by ion mobility spectroscopy has become common in recent years. We demonstrate explosive detection with a novel Laser Ion Mobility Spectrometer (LIMS) developed at EADS Innovation Works. A Laser operating at 266nm was used for the two-photon ionisation of dopant and calibrant substances. Quantitative measurements of trace residues of explosives have been performed to quantify the sensitivity of the LIMS system. Findings demonstrate the suitability of this technique as a screening tool for explosive compounds.© (2009) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.