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Proceedings Article

Near-infrared spectroscopy of the bladder: a new technique for studying lower urinary tract function in health and disease

[+] Author Affiliations
Babak Shadgan, Kourosh Afshar, Lynn Stothers

The Univ. of British Columbia (Canada)

Andrew Macnab

The Univ. of British Columbia (Canada) and Wallenberg Research Ctr. (South Africa)

Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75480U (March 02, 2010); doi:10.1117/12.841066
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From Conference Volume 7548

  • Photonic Therapeutics and Diagnostics VI
  • Nikiforos Kollias; Bernard Choi; Haishan Zeng; Reza S. Malek; Brian J. Wong; Justus F. R. Ilgner; Kenton W. Gregory; Guillermo J. Tearney; Laura Marcu; Henry Hirschberg; Steen J. Madsen; Andreas Mandelis; Anita Mahadevan-Jansen; E. Duco Jansen
  • San Francisco, California | January 23, 2010

abstract

Background: Continuous wave near-infrared spectroscopy (NIRS) can monitor chromophore change in the bladder detrusor muscle during voiding; oxygenation and hemodynamic data derived differ in health and disease. Application of wireless NIRS for evaluation of voiding dysfunction would benefit children. Methods: Subjects: 20 children (4-17 yrs) [5 normal, 15 with urinary tract pathology]. Instrumentation: self-contained device weight 84 gm; 3 paired light emitting diodes (760/850 nm) in a spatially resolved configuration; source-detector separation distances (30, 35 and 40 mm); silicon photodiode detector; and Bluetooth®. Procedure: Transcutaneous monitoring (midline abdominal skin 2 cm above pubis) during spontaneous voiding (bladder contraction) of oxygenated (O2Hb), deoxygenated (HHb) and total hemoglobin (tHb) and tissue oxygen saturation index (TSI %) at 10 Hz. Results: All 20 trials produced clear graphic data with no movement effect evident. Comparison of patterns of chromophore change between normal and symptomatic subjects revealed trend differences in O2Hb and tHb. (Normal positive; Symptomatic negative, and TSI% fell in symptomatic group). Conclusions: Wireless NIRS is technically feasible in ambulant children. Negative trends in chromophore concentration and falls in TSI% suggest a hemodynamic impairment may underlie some forms of voiding dysfunction, with abnormal physiology involving the microcirculation possibly resulting in muscle fatigue during voiding.

© (2010) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Babak Shadgan ; Kourosh Afshar ; Lynn Stothers and Andrew Macnab
"Near-infrared spectroscopy of the bladder: a new technique for studying lower urinary tract function in health and disease", Proc. SPIE 7548, Photonic Therapeutics and Diagnostics VI, 75480U (March 02, 2010); doi:10.1117/12.841066; http://dx.doi.org/10.1117/12.841066


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